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[DYSPHAGIA] Globus etc.
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Irene,
I am unclear on this. Is it soley the reflux (or is it also the drugs =
mentioned) that increases the risk of cancer? And if so, why? Thanks =
in advance for the information.
--Andrea, mom to a 5.5 year old with reflux (but can eat great orally =
since e-stim therapy over a year ago!)
Reflux-Causing Medications Linked to Increase in Esophageal Cancer =
Incidence=20
The introduction and increasing use of several medications that can =
cause gastroesophageal reflux, particularly anticholinergic agents, may =
play an important role in the rising incidence of esophageal =
adenocarcinoma.=20
The investigators note that reflux is known to be a major risk factor =
for esophageal adenocarcinoma. They measured the link between cancer and =
the use of drugs that relax the lower esophageal sphincter - =
nitroglycerin, aminophyllines, beta-adrenergic agonists, anticholinergic =
drugs and benzodiazepines - in more than 600 patients with esophageal =
adenocarcinoma, adenocarcinoma of the gastric cardia or esophageal =
squamous-cell carcinoma, and 820 controls.=20
Long-term, daily use of esophageal sphincter-relaxing drugs =
significantly increased the risk of esophageal adenocarcinoma by =
3.8-fold. The association was strong for all classes of drugs, but =
particularly for anticholinergics. =20
Gastroesophageal reflux can lead to a rapidly fatal condition, and =
therefore is more than just a little heartburn. =20
Ann Intern Med 2000;133:165-229.
Irene.
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<DIV>
<DIV><FONT face=3DArial size=3D2>Irene,</FONT></DIV>
<DIV><FONT face=3DArial size=3D2>I am unclear on this. Is it soley =
the reflux=20
(or is it also the drugs mentioned) that increases the risk of =
cancer? And=20
if so, why? Thanks in advance for the information.</FONT></DIV>
<DIV><FONT face=3DArial size=3D2>--Andrea, mom to a 5.5 year old with =
reflux (but=20
can eat great orally since e-stim therapy over a year =
ago!)</FONT></DIV></DIV>
<BLOCKQUOTE dir=3Dltr=20
style=3D"PADDING-RIGHT: 0px; PADDING-LEFT: 5px; MARGIN-LEFT: 5px; =
BORDER-LEFT: #000000 2px solid; MARGIN-RIGHT: 0px">
<DIV style=3D"FONT: 10pt arial"><SPAN=20
style=3D"FONT-SIZE: 11pt; FONT-FAMILY: Arial; mso-bidi-font-size: =
10.0pt">Reflux-Causing=20
Medications Linked to Increase in Esophageal Cancer=20
Incidence </SPAN></DIV>
<DIV>
<P class=3DMsoNormal><SPAN=20
style=3D"FONT-SIZE: 11pt; FONT-FAMILY: Arial; mso-bidi-font-size: =
10.0pt">The=20
introduction and increasing use of several medications that can cause=20
gastroesophageal reflux, particularly anticholinergic agents, may play =
an=20
important role in the rising incidence of esophageal </SPAN><SPAN=20
style=3D"FONT-SIZE: 11pt; FONT-FAMILY: Arial; mso-bidi-font-size: =
10.0pt">adenocarcinoma. </SPAN></P>
<P class=3DMsoNormal><SPAN=20
style=3D"FONT-SIZE: 11pt; FONT-FAMILY: Arial; mso-bidi-font-size: =
10.0pt">The=20
investigators note that reflux is known to be a major risk factor for=20
esophageal adenocarcinoma. They measured the link between cancer and =
the use=20
of drugs that relax the lower esophageal sphincter — =
nitroglycerin,=20
aminophyllines, beta-adrenergic agonists, anticholinergic drugs and=20
benzodiazepines — in more than 600 patients with esophageal =
adenocarcinoma,=20
adenocarcinoma of the gastric cardia or esophageal<SPAN=20
style=3D"mso-spacerun: yes"> </SPAN>squamous-cell carcinoma, and =
820=20
controls. </SPAN></P>
<P class=3DMsoNormal><SPAN=20
style=3D"FONT-SIZE: 11pt; FONT-FAMILY: Arial; mso-bidi-font-size: =
10.0pt">Long-term,=20
daily use of esophageal sphincter-relaxing drugs significantly =
increased the=20
risk of esophageal adenocarcinoma by 3.8-fold. The association was =
strong for=20
all classes of drugs, but particularly for =
anticholinergics. </SPAN><SPAN=20
style=3D"FONT-SIZE: 11pt; FONT-FAMILY: Arial; mso-bidi-font-size: =
10.0pt"> <o:p></o:p></SPAN></P>
<P class=3DMsoNormal><SPAN=20
style=3D"FONT-SIZE: 11pt; FONT-FAMILY: Arial; mso-bidi-font-size: =
10.0pt">Gastroesophageal=20
reflux can lead to a rapidly fatal condition, and therefore is more =
than just=20
a little heartburn. </SPAN><SPAN=20
style=3D"FONT-SIZE: 11pt; FONT-FAMILY: Arial; mso-bidi-font-size: =
10.0pt"> <o:p></o:p></SPAN></P>
<P class=3DMsoNormal><SPAN=20
style=3D"FONT-SIZE: 11pt; FONT-FAMILY: Arial; mso-bidi-font-size: =
10.0pt">Ann=20
Intern Med 2000;133:165-229.</SPAN></P>
<P class=3DMsoNormal><SPAN=20
style=3D"FONT-SIZE: 11pt; FONT-FAMILY: Arial; mso-bidi-font-size: =
10.0pt"><o:p>Irene.</o:p></SPAN></P></DIV></BLOCKQUOTE></BODY></HTML>
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